- Alice in Wonderland (2010)- The Mad Hatter
- Public Enemies (2009)- John Dillinger
- The Imaginarium of Doctor Parnassus (2009)- Imaginarium Tony #1
- Sweeney Todd: The Demon Barber of Fleet Street (2007)- Sweeney Todd
- Pirates of the Caribbean: At World’s End (2007)- Jack Sparrow
- Pirates of the Caribbean: Dead Man’s Chest (2006)- Jack Sparrow
- Corpse Bride (2005)- Victor Van Dort (voice)
- Charlie and the Chocolate Factory (2005)- Willy Wonka
- The Libertine (2004)- Rochester
- Finding Neverland (2004)- Sir James Matthew Barrie
- And They Lived Happily Ever After (2004)- L’inconnu. The DVD title is ‘Happily Ever After’.
- Secret Window (2004)- Mort Rainey
- Once Upon a Time in Mexico (2003)- Sands
- Pirates of the Caribbean: The Curse of the Black Pearl (2003)- Jack Sparrow
- From Hell (2001)- Inspector Frederick Abberline
- Blow (2001)- George Jung
- Chocolat (2000)- Roux
- Before Night Falls (2000)- Bon Bon / Lieutenant Victor
- The Man Who Cried (2000)- Cesar
- Sleepy Hollow (1999)- Ichabod Crane
- The Astronaut’s Wife (1999)- Commander Spencer Armacost
- The Ninth Gate (1999)- Dean Corso
- Fear and Loathing in Las Vegas (1998)- Raoul Duke
- The Brave (1997)- Raphael. Depp also directed this film.
- Donnie Brasco (1997)- Donnie Brasco / Joseph D. ‘Joe’ Pistone
- Nick of Time (1995)- Gene Watson
- Dead Man (1995)- William Blake
- Don Juan DeMarco (1994)- Don Juan
- Ed Wood (1994)- Ed Wood
- What’s Eating Gilbert Grape (1993)- Gilbert Grape
- Benny & Joon (1993)- Sam
- Arizona Dream (1993)- Axel Blackmar. The film is also known as ‘The Arrowtooth Waltz’.
- Freddy’s Dead: The Final Nightmare- Guy on TV
- Edward Scissorhands (1990)- Edward Scissorhands
- Cry-Baby (1990)- Cry-Baby
- Platoon (1986)- Lerner
- Slow Burn (1986- television movie)- Donnie Fleischer
- Private Resort (1985)- Jack
- A Nightmare on Elm Street (1984)- Glen Lantz